Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

机译：移植后GMP级无异种hESC衍生RPE细胞的长期功效

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摘要

PurposeRetinal pigment epithelium (RPE) dysfunction underlies the retinal degenerative process in age-related macular degeneration (AMD), and thus RPE cell replacement provides an optimal treatment target. We characterized longitudinally the efficacy of RPE cells derived under xeno-free conditions from clinical and xeno-free grade human embryonic stem cells (OpRegen) following transplantation into the subretinal space of Royal College of Surgeons (RCS) rats.

机译：目的视网膜色素上皮（RPE）功能障碍是年龄相关性黄斑变性（AMD）中视网膜变性过程的基础，因此，RPE细胞置换提供了最佳治疗靶点。我们纵向表征了在无异种条件下从临床和无异种等级的人类胚胎干细胞（OpRegen）衍生的RPE细胞的功效，其被移植到皇家外科医学院（RCS）大鼠的视网膜下空间。

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期刊名称 Translational Vision Science Technology
作者
Trevor J. McGill; Osnat Bohana-Kashtan; Jonathan W. Stoddard; Michael D. Andrews; Neelay Pandit; Lior R. Rosenberg-Belmaker; Ofer Wiser; Limor Matzrafi; Eyal Banin; Benjamin Reubinoff; Nir Netzer; Charles Irving;
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作者单位

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年(卷),期 -1(6),3
年度 -1
页码 17
总页数 18
原文格式 PDF
正文语种
中图分类眼科学;
关键词
RPE cells transplantation AMD Xeno-free;

机译：RPE细胞;移植;AMD;无Xeno;

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专利

1. Elucidating the phenomenon of HESC-derived RPE: anatomy of cell genesis, expansion and retinal transplantation. [J] . Vugler A, Carr AJ, Lawrence J, Experimental Neurology . 2008,第2期

机译：阐明HESC衍生的RPE现象：细胞起源，扩张和视网膜移植的解剖。
2. Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34 + cells in NOD-SCID mice with acute ischemia-reperfusion injury [J] . ParkS.S., CaballeroS., BauerG., Investigative ophthalmology & visual science . 2012,第2期

机译：玻璃体内注射GMP级骨髓源CD34 +细胞对NOD-SCID小鼠急性缺血再灌注损伤的长期影响
3. Long-Term Effects of Intravitreal Injection of GMP-Grade Bone-Marrowa??Derived CD34+ Cells in NOD-SCID Mice with Acute Ischemia-Reperfusion Injury [J] . Susanna S. Park, Sergio Caballero, Gerhard Bauer, Investigative ophthalmology & visual science . 2012,第2期

机译：玻璃体腔内注射GMP级骨髓Marrowa ?? CD34 +细胞在NOD-SCID小鼠急性缺血再灌注损伤中的长期作用。
4. The development and characterization of a high throughput biomaterial matrix microarray to identify xeno-free and feeder layer-free culture substrates for long-term maintenance of human pluripotent stem cells [C] . Ronald G Ireland, Justin Pang, Mark Kibschull, World biomaterials congress . 2016

机译：开发和表征高通量生物材料基质微阵列，以鉴定无异种和无饲养层的培养基质，以长期维持人多能干细胞
5. Long-Term Bone Mineral Density Loss Following Autologous and Allogeneic Hematopoietic Cell Transplantation and Effectiveness of Bone Loss Therapies to Combat the Loss. [D] . Croudy, Christopher M. 2012

机译：自体和同种异体造血细胞移植后的长期骨矿物质密度损失以及抗击骨损失疗法的有效性。
6. Derivation of Xeno-Free and GMP-Grade Human Embryonic Stem Cells – Platforms for Future Clinical Applications [O] . Shelly E. Tannenbaum, Tikva Tako Turetsky, Orna Singer, 2009

机译：无异种和GMP级人类胚胎干细胞的衍生-未来临床应用的平台
7. Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation [O] . Trevor J. McGill, Osnat Bohana-Kashtan, Jonathan W. Stoddard, 2017

机译：移植后，GMP级异种HESCHESC衍生RPE细胞的长期疗效

Long-Term Efficacy of GMP Grade Xeno-Free hESC-Derived RPE Cells Following Transplantation

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