Association of Tumor Necrosis Factor-α–238GA and Apolipoprotein E2 Polymorphisms with Intracranial Hemorrhage after Brain Arteriovenous Malformation Treatment

摘要

OBJECTIVEWe previously reported specific genotypes of polymorphisms in two genes, tumor necrosis factor-α (TNF-α-238G>A) and Apolipoprotein E (ApoE e2), as independent predictors of new intracranial hemorrhage (ICH) in the natural course of untreated brain arteriovenous malformations. We hypothesized that the risk of post-treatment ICH would also be greater in patients with brain arteriovenous malformations with these genotypes.