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Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models

机译：Mad2 siRNA载EGFR靶向壳聚糖纳米颗粒在顺铂敏感性和耐药性肺癌模型中的生物分布和药代动力学

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摘要

>Background: The present study focuses on biodistribution profile and pharmacokinetic parameters of EGFR-targeted chitosan nanoparticles (TG CS nanoparticles) for siRNA/cisplatin combination therapy of lung cancer.

机译：>背景：本研究的重点是针对siRNA /顺铂联合治疗肺癌的EGFR靶向壳聚糖纳米颗粒（TG CS纳米颗粒）的生物分布特征和药代动力学参数。

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期刊名称 Nanomedicine
作者
Ana Vanessa Nascimento; Florence Gattacceca; Amit Singh; Hassan Bousbaa; Domingos Ferreira; Bruno Sarmento; Mansoor M Amiji;
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作者单位

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年(卷),期 -1(11),7
年度 -1
页码 767–781
总页数 15
原文格式 PDF
正文语种
中图分类应用微生物学;
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专利

1. Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models [J] . Nascimento Ana Vanessa, Gattacceca Florence, Singh Amit, Nanomedicine . 2016,第7期

机译：在顺铂敏感和耐药的肺癌模型中，Mad2 siRNA加载的EGFR靶向壳聚糖纳米粒子的生物分布和药代动力学。
2. Mad2 checkpoint gene silencing using epidermal growth factor receptor-targeted chitosan nanoparticles in non-small cell lung cancer model [J] . NascimentoA.V., SinghA., BousbaaH., Molecular pharmaceutics . 2014,第10期

机译：在非小细胞肺癌模型中使用表皮生长因子受体靶向的壳聚糖纳米颗粒对Mad2检查点基因进行沉默
3. Dual drug-loaded biofunctionalized amphiphilic chitosan nanoparticles: Enhanced synergy between cisplatin and demethoxycurcumin against multidrug-resistant stem-like lung cancer cells [J] . Huang Wei-Ting, Larsson Mikael, Lee Yi-Chi, European journal of pharmaceutics and biopharmaceutics: official journal of Arbeitsgemeinschaft fuer Pharmazeutische Verfahrenstechnik e.V . 2016,第Null期

机译：载有双重药物的生物功能化两亲性壳聚糖纳米颗粒：顺铂和去甲氧基姜黄素增强对多重耐药性干细胞样肺癌细胞的协同作用
4. HPMA HYDROGEL-BASED DRUG DELIVERY SYSTEM: PHARMACOKINETIC AND IN VIVO EFFICACY IN SENSITIVE AND MULTIDRUG RESISTANT CANCER MODELS [C] . M. Stastny, D. Plocova, K. Ulbrich, International symposium on controlled release of bioactive materials;Consumer diversified products conference . 2001

机译：基于HPMA水凝胶的药物输送系统：敏感和多药耐药癌症模型中的药动学和体内药效
5. Pharmacokinetics and Biodistribution of 89Zr-Df-PEG40 Nanoparticles in Xenograft Tumor Models Using Micro PET/CT [D] . Trusz, Guillaume. 2018

机译：使用Micro PET / CT的卵黄移植肿瘤模型89ZR-DF-PEG40纳米粒子的药代动力学和生物分布
6. Overcoming Cisplatin Resistance in Non-Small Cell Lung Cancer with Mad2 Silencing siRNA Delivered Systemically using EGFR-Targeted Chitosan Nanoparticles [O] . Ana Vanessa Nascimento, Amit Singh, Hassan Bousbaa, -1

机译：通过使用EGFR靶向的壳聚糖纳米粒子系统递送的Mad2沉默siRNA克服非小细胞肺癌的顺铂耐药性。
7. Biodistribution and pharmacokinetics ofMad2siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models [O] . Ana Vanessa Nascimento, Florence Gattacceca, Amit Singh, 2016

机译：在顺铂敏感和抗性肺癌模型中的MMAD2SiRNA加载的EGFR靶向壳聚糖纳米粒子的生物分布和药代动力学

Biodistribution and pharmacokinetics of Mad2 siRNA-loaded EGFR-targeted chitosan nanoparticles in cisplatin sensitive and resistant lung cancer models

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