Targeted buccal delivery containing cisplatin filled chitosan nanoparticles

摘要

Delivery devices have been developed for local and systemic delivery of drugs to targeted oral locations, such as cancer cells of the mouth. The formulation comprises a mucoadhesive polymer containing one or more therapeutic and / or diagnostic agents to be delivered, a taste masking agent, a penetration enhancer, and a hydrophilic polymer coating, eg, polyethylene glycol (“PEG”). Contains a matrix, such as chitosan. In one aspect, a formulation for delivering a drug to a site within a mucosal cavity is provided, wherein the formulation includes a mucoadhesive polymer matrix having nanoparticles, wherein the nanoparticles are incorporated into the nanoparticles. A therapeutic agent, a preventive agent, a diagnostic agent, or a nutritional supplement, wherein the therapeutic agent, the prophylactic agent, the diagnostic agent, or the nutritional supplement is taste-masked or the mucosa Target tissue during release in the cavity.