Activated CD4+ T Cells Target Mesangial Antigens and Initiate Glomerulonephritis

机译：活化的CD4 + T细胞靶向肾小球膜抗原并引发肾小球肾炎

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AimsThe role of kidney infiltrating T cells in the pathology of lupus nephritis is unclear. This study was undertaken to investigate whether CD4+ T cell responses to a surrogate mesangial antigen can initiate glomerulonephritis.

机译：目的尚不清楚肾浸润性T细胞在狼疮性肾炎病理中的作用。进行这项研究以调查对替代性系膜抗原的CD4 + T细胞反应是否可以引发肾小球肾炎。

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期刊名称 Nephron. Experimental Nephrology
作者
Yogesh Scindia; Dominika Nackiewicz; Paromita Dey; Agneiszka Szymula; Amandeep Bajwa; Diane Rosin; W. Kline Bolton; Mark Okusa; Umesh Deshmukh; Harini Bagavant;
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年(卷),期 -1(121),1-2
年度 -1
页码 e1–e9
总页数 15
原文格式 PDF
正文语种
中图分类泌尿科学（泌尿生殖系疾病）;小儿泌尿科学;肾疾病;
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专利

1. Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses [J] . Hongyu Yu, Shaoyuan Cui, Yan Mei, Journal of immunology research. . 2019,第1期

机译：Mesangial细胞表现出抗原呈递细胞的特征，并激活CD4 + T细胞反应
2. Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif [J] . Lichtnekert, J., Vielhauer, American Journal of Physiology . 2009,第4aPta2期

机译：免疫复合肾小球肾炎不需要TRIF：染色细胞通过TLR2 / MYD88而不是TLR3 / TRIF激活Mesangial细胞
3. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL. [J] . Matte-Martone C, Liu J, Jain D, Blood: The Journal of the American Society of Hematology . 2008,第7期

机译：CD8 +而不是CD4 + T细胞需要与靶组织发生同源相互作用才能介导GVHD仅跨过较小的H抗原，而CD4 +和CD8 + T细胞都需要直接白血病接触才能介导GVL。
4. ADVANCES OF TARGETING DRUG DELIVERLY TO GLOMERULAR MESANGIAL CELLS BY LONG CIRCULATING CATIONIC LIPOSOMES FOR TREATMENT OF GLOMERULONEPHRITIS [C] . K. Morimoto, T. Ikeda, T. Harigai, Proceedings of the 29th Annual Meeting of the Controlled Release Society . 2002

机译：长期循环阳离子脂质体靶向治疗肾小球肾小球系膜细胞的研究
5. Graft antigen-specific CD4+ T cells require CD154 expression to clonally expand and differentiate to the TH1 phenotype and initiate mTOR dependant intimal hyperplasia in cardiac allografts. [D] . Huddleston, Stephen James. 2009

机译：嫁接抗原特异性CD4 + T细胞需要CD154表达才能克隆扩增并分化为TH1表型，并在心脏同种异体移植中引发mTOR依赖性内膜增生。
6. Mesangial Cells Exhibit Features of Antigen-Presenting Cells and Activate CD4+ T Cell Responses [O] . Hongyu Yu, Shaoyuan Cui, Yan Mei, 2019

机译：肾小球系膜细胞表现出抗原呈递细胞的特征并激活CD4 + T细胞反应
7. Activated CD4+ T Cells Target Mesangial Antigens and Initiate Glomerulonephritis [O] . Yogesh Scindia, Dominika Nackiewicz, Paromita Dey, 2012

机译：活化的CD4 + T细胞靶位抗原并引发肾小球肾炎
8. Costimulation of T Cell Receptor/CD3-Mediated Activation of Resting Human CD4+ TCells by Leukocyte Function-Associated Antigen-1 Ligand Intercellular Cell Adhesion Molecule-1 Involves Prolonged Inositol Phospholipid Hydrolysis and Sustained Increase of In [R] . Van Seventer, G. A., Bonvini, E., Yamada, H., 1992

机译：白细胞功能相关抗原-1配体细胞间粘附分子-1的T细胞受体/ CD3介导的静息人CD4 + TCell活化共刺激涉及延长的肌醇磷脂水解和持续增加的In

Activated CD4+ T Cells Target Mesangial Antigens and Initiate Glomerulonephritis

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