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美国卫生研究院文献>The Journal of Nutrition
>Lifestyle Counseling and Supplementation with Flaxseed or Walnuts Influence the Management of Metabolic Syndrome
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Lifestyle Counseling and Supplementation with Flaxseed or Walnuts Influence the Management of Metabolic Syndrome
A healthy lifestyle may ameliorate metabolic syndrome (MetS); however, it remains unclear if incorporating nuts or seeds into lifestyle counseling (LC) has additional benefit. A 3-arm, randomized, controlled trial was conducted among 283 participants screened for MetS using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans. Participants were assigned to a LC on the AHA guidelines, LC + flaxseed (30 g/d) (LCF), or LC + walnuts (30 g/d) (LCW) group. After the 12-wk intervention, the prevalence of MetS decreased significantly in all groups: −16.9% (LC), −20.2% (LCF), and −16.0% (LCW). The reversion rate of MetS, i.e. those no longer meeting the MetS criteria at 12 wk, was not significantly different among groups (LC group, 21.1%; LCF group, 26.6%; and LCW group, 25.5%). However, the reversion rate of central obesity was higher in the LCF (19.2%; P = 0.008) and LCW (16.0%; P = 0.04) groups than in the LC group (6.3%). Most of the metabolic variables (weight, waist circumference, serum glucose, total cholesterol, LDL cholesterol, apolipoprotein (Apo) B, ApoE, and blood pressure) were significantly reduced from baseline in all 3 groups. However, the severity of MetS, presented as the mean count of MetS components, was significantly reduced in the LCW group compared with the LC group among participants with confirmed MetS at baseline (P = 0.045). Our results suggest that a low-intensity lifestyle education program is effective in MetS management. Flaxseed and walnut supplementation may ameliorate central obesity. Further studies with larger sample sizes and of longer duration are needed to examine the role of these foods in the prevention and management of MetS.
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机译:健康的生活方式可能会改善代谢综合征(MetS);但是,尚不清楚将坚果或种子掺入生活方式咨询(LC)是否还会带来额外的好处。使用更新的《美国国家胆固醇教育计划成人治疗小组III亚裔美国人标准》,在283名筛查MetS的参与者中进行了3组随机对照试验。根据AHA指南将参与者分为LC,LC +亚麻籽(30 g / d)(LCF)或LC +核桃(30 g / d)(LCW)组。在12周干预后,所有组中MetS的患病率均显着降低:-16.9%(LC),-20.2%(LCF)和-16.0%(LCW)。各组之间MetS的恢复率(即不再满足MetS标准的恢复率)在各组之间没有显着差异(LC组为21.1%; LCF组为26.6%; LCW组为25.5%)。然而,LCF组(19.2%; P = 0.008)和LCW组(16.0%; P = 0.04)的中枢性肥胖逆转率高于LC组(6.3%)。在所有三个组中,大多数代谢变量(体重,腰围,血糖,总胆固醇,LDL胆固醇,载脂蛋白(Apo)B,ApoE和血压)均显着降低。然而,与基线水平确诊MetS的参与者相比,LCW组的MetS严重性(以MetS成分的平均计数表示)显着降低(P = 0.045)。我们的结果表明,低强度的生活方式教育计划在MetS管理中是有效的。亚麻籽和核桃仁的补充可以减轻中枢型肥胖。需要进行更大样本量和更长持续时间的进一步研究,以检查这些食物在预防和管理MetS中的作用。
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