Regulation of crp gene expression by the catabolite repressor/activator Cra in Escherichia coli

摘要

Growth on several carbon sources is dependent on the catabolite repressor/activator (Cra) protein although a Cra consensus DNA binding site is not present in the control regions of the relevant catabolic operons. We show that Cra regulates growth by activating expression of the crp gene. It thereby mediates catabolite repression of catabolic operons by an indirect mechanism.