首页> 美国卫生研究院文献>Journal of Clinical Oncology >Phase I Trial of Polifeprosan 20 With Carmustine Implant Plus Continuous Infusion of Intravenous O6-Benzylguanine in Adults With Recurrent Malignant Glioma: New Approaches to Brain Tumor Therapy CNS Consortium Trial

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Phase I Trial of Polifeprosan 20 With Carmustine Implant Plus Continuous Infusion of Intravenous O6-Benzylguanine in Adults With Recurrent Malignant Glioma: New Approaches to Brain Tumor Therapy CNS Consortium Trial

机译：Polifeprosan 20的I期试验（加有卡莫司汀植入物和连续输注成人恶性神经胶质瘤的静脉注射O6-苄基鸟嘌呤）：脑肿瘤治疗CNS联合体试验的新方法

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PurposeThis phase I trial was designed to (1) establish the dose of O⁶-benzylguanine (O⁶-BG) administered intravenously as a continuous infusion that suppresses O⁶-alkylguanine-DNA alkyltransferase (AGT) levels in brain tumors, (2) evaluate the safety of extending continuous-infusion O⁶-BG at the optimal dose with intracranially implanted carmustine wafers, and (3) measure the pharmacokinetics of O⁶-BG and its metabolite.

机译：目的该I期试验旨在（1）确定以连续输注方式抑制O ^{的静脉输注O ^{6 -苄基鸟嘌呤（O ^{6 -BG）的剂量脑肿瘤中6 -烷基鸟嘌呤-DNA烷基转移酶（AGT）的水平，（2）评价了在颅内植入卡莫司汀片的最佳剂量下连续输注O ^{6 -BG的安全性，（3）测量O ^{6 -BG及其代谢产物的药代动力学。}}}}}

著录项

期刊名称 Journal of Clinical Oncology
作者
Jon Weingart; Stuart A. Grossman; Kathryn A. Carson; Joy D. Fisher; Shannon M. Delaney; Mark L. Rosenblum; Alessandro Olivi; Kevin Judy; Stephen B. Tatter; M. Eileen Dolan;
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年(卷),期 -1(25),4
年度 -1
页码 399–404
总页数 12
原文格式 PDF
正文语种
中图分类肿瘤学;
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1. Phase I trial of polifeprosan 20 with carmustine implant plus continuous infusion of intravenous O6-benzylguanine in adults with recurrent malignant glioma: new approaches to brain tumor therapy CNS consortium trial. [J] . Weingart J, Grossman SA, Carson KA, Journal of Clinical Oncology . 2007,第4期

机译：成年复发性恶性神经胶质瘤成人患者中加用卡莫司汀植入物的polifeprosan 20 I期试验，连续输注静脉内O6-苄基鸟嘌呤：脑肿瘤治疗CNS联合体试验的新方法。
2. Dose escalation of carmustine in surgically implanted polymers in patients with recurrent malignant glioma: a new approaches to brain tumor therapy CNS consortium trial. [J] . Olivi A, Grossman SA, Tatter S, Journal of Clinical Oncology . 2003,第9期

机译：复发性恶性神经胶质瘤患者手术植入的聚合物中卡莫司汀的剂量升高：脑肿瘤治疗CNS联合体试验的新方法。
3. Prognostic factors for survival in adult patients with recurrent glioma enrolled onto the new approaches to brain tumor therapy CNS consortium phase I and II clinical trials. [J] . Carson KA, Grossman SA, Fisher JD, Journal of Clinical Oncology . 2007,第18期

机译：成年复发性神经胶质瘤患者生存的预后因素纳入了脑肿瘤治疗CNS联合I和II期临床试验的新方法。
4. Clinical trials of photodynamic therapy of malignant brain tumors [C] . Author(s): Paul J. Muller M.D. St. Michaels Hospital and the Princess Margaret Hosp ital/Univ. of Toronto Toronto ON Canada, Brian C. Wilson St. Michaels Hospital and the Princess Margaret Hosp ital/Univ. of Toronto Toronto ON Canada, Lothar D. Lilge St. Michaels Hospital and the Princess Margaret Hosp ital/Univ. of Toronto Toronto ON Canada, Conference on optical methods for tumor treatment and detection: Mechanisms and techniques in photodynamic therapy . 2000

机译：光动力疗法治疗恶性脑肿瘤的临床试验
5. Prognostic Factors for Survival in Adult Patients with Recurrent Glioma Enrolled on New Approaches to Brain Tumor Therapy NABTT CNS Consortium Phase I and II Clinical Trials [O] . Kathryn A. Carson, Stuart A. Grossman, Joy D. Fisher, -1

机译：成年复发性脑胶质瘤患者生存的预后因素纳入脑瘤治疗新方法 NABTT CNS联合会I和II期临床试验
6. Prognostic Factors for Survival in Adult Patients With Recurrent Glioma Enrolled Onto the New Approaches to Brain Tumor Therapy CNS Consortium Phase I and II Clinical Trials [O] . Kathryn A. Carson, Stuart A. Grossman, Joy D. Fisher, 2007

机译：预后因素用于成人患者复发性胶质瘤的患者进入脑肿瘤治疗CNS联盟I和II临床试验的新方法

Phase I Trial of Polifeprosan 20 With Carmustine Implant Plus Continuous Infusion of Intravenous O6-Benzylguanine in Adults With Recurrent Malignant Glioma: New Approaches to Brain Tumor Therapy CNS Consortium Trial

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