Src-Family Tyrosine Kinases in Wound- and Ligand-Induced Epidermal Growth Factor Receptor Activation in Human Corneal Epithelial Cells

摘要

PurposeThe authors have previously demonstrated that wounding of human corneal epithelial cells (HCECs) transactivates epidermal growth factor (EGF) receptor (EGFR) and its downstream signaling pathways and that this EGFR signaling is required for epithelial wound healing. In this study, the authors sought to identify the underlying mechanisms for EGFR transactivation in response to wounding in HCECs.