首页> 美国卫生研究院文献>Journal of Cell Science >Integrating one-dimensional and three-dimensional maps of genomes
【2h】

Integrating one-dimensional and three-dimensional maps of genomes

机译:整合基因组的一维和三维图

代理获取
本网站仅为用户提供外文OA文献查询和代理获取服务,本网站没有原文。下单后我们将采用程序或人工为您竭诚获取高质量的原文,但由于OA文献来源多样且变更频繁,仍可能出现获取不到、文献不完整或与标题不符等情况,如果获取不到我们将提供退款服务。请知悉。
获取外文期刊封面目录资料

摘要

Genomes exist in vivo as complex physical structures, and their functional output (i.e. the gene expression profile of a cell) is related to their spatial organization inside the nucleus as well as to local chromatin status. Chromatin modifications and chromosome conformation are distinct in different tissues and cell types, which corresponds closely with the diversity in gene-expression patterns found in different tissues of the body. The biological processes and mechanisms driving these general correlations are currently the topic of intense study. An emerging theme is that genome compartmentalization – both along the linear length of chromosomes, and in three dimensions by the spatial colocalization of chromatin domains and genomic loci from across the genome – is a crucial parameter in regulating genome expression. In this Commentary, we propose that a full understanding of genome regulation requires integrating three different types of data: first, one-dimensional data regarding the state of local chromatin – such as patterns of protein binding along chromosomes; second, three-dimensional data that describe the population-averaged folding of chromatin inside cells and; third, single-cell observations of three-dimensional spatial colocalization of genetic loci and trans factors that reveal information about their dynamics and frequency of colocalization.
机译:基因组在体内以复杂的物理结构存在,其功能输出(即细胞的基因表达谱)与其在细胞核内的空间组织以及局部染色质状态有关。染色质修饰和染色体构象在不同的​​组织和细胞类型中是不同的,这与在人体的不同组织中发现的基因表达模式的多样性紧密对应。驱动这些一般相关性的生物学过程和机制目前是深入研究的主题。一个新兴的主题是,基因组区划(在整个染色体的线性长度上以及在整个维度上通过染色质域和整个基因组的基因组基因座在空间上的共定位在三个维度上)都是调节基因组表达的关键参数。在本评论中,我们建议对基因组调控的全面理解需要整合三种不同类型的数据:第一,关于局部染色质状态的一维数据,例如沿着染色体的蛋白质结合模式;第二,三维数据,描述了染色质在细胞内的群体平均折叠,以及第三,对遗传基因座和反式因子的三维空间共定位的单细胞观察,揭示了它们的动态关系和共定位频率。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
代理获取

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号