Natural and Orthogonal Interaction framework for modeling gene-environment interactions with application to lung cancer

摘要

ObjectivesWe aimed at extending the natural and orthogonal interaction (NOIA) framework, developed for modeling gene-gene interactions in the analysis of quantitative traits, to allow for reduced genetic models, dichotomous traits, and gene-environment interactions. We evaluate the performance of the NOIA statistical models using simulated data and lung cancer data.