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OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects

机译：脂肪细胞中的OCT1表达可能有助于肥胖受试者二甲双胍的作用增加。

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OBJECTIVEMetformin has been well characterized in vitro as a substrate of liver-expressed organic cation transporters (OCTs). We investigated the gene expression and protein levels of OCT-1 and OCT-2 in adipose tissue and during adipogenesis and evaluated their possible role in metformin action on adipocytes.

机译：目的二甲双胍在体外已被很好地表征为肝脏表达的有机阳离子转运蛋白（OCT）的底物。我们调查了脂肪组织中和脂肪形成过程中OCT-1和OCT-2的基因表达和蛋白水平，并评估了它们在二甲双胍对脂肪细胞作用中的可能作用。

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期刊名称 Diabetes
作者
José María Moreno-Navarrete; Francisco J. Ortega; José-Ignacio Rodríguez-Hermosa; Mònica Sabater; Gerard Pardo; Wifredo Ricart; José Manuel Fernández-Real;
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作者单位

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年(卷),期 2011(60),1
年度 2011
页码 168–176
总页数 9
原文格式 PDF
正文语种
中图分类基础医学;
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1. OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects [J] . José María Moreno-Navarrete Francisco J Ortega José-Ignacio Rodríguez-Hermosa Mònica Sabater Gerard Pardo Wifredo Ricart José Manuel Fernández-Real Diabetes . 2011,第1期

机译：脂肪细胞中的OCT1表达可能有助于肥胖受试者二甲双胍的作用增加。
2. OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects [J] . Jose Maria Moreno-Navarrete Francisco J. Ortega, Jose-Ignacio Rodriguez-Hermosa, Monica Sabater, Diabetes . 2011,第1期

机译：脂肪细胞中的OCT1表达可能有助于肥胖受试者二甲双胍的作用增加。
3. Depot- and obesity-related differences in adipogenesisAdipocyte hypertrophy and hyperplasia are known to facilitate lipid storage in adipose tissues by increasing adipocyte cell size and number, respectively. Adipogenesis is the process resulting in adipose tissue hyperplasia. Although depot-specific differences and obesity-related modulation of adipocyte size are well documented, available data on adipogenesis and adipose tissue hyperplasia are less conclusive. Most studies support a reduction of adipogenesis in the obese state. Preadipocytes of the subcutaneous fat depot appear to be more responsive to adipogenic stimulation compared with those from visceral fat compartments in most studies. A number of studies support the notion that adipose tissue expansion through hyperplasia reduces ectopic lipid excess and obesity-related complications. Several genetic variants have been identified in the genes coding for adipogenesis-regulating proteins. While some of these variants have been clearly associated with the phenotypes of obesity and obesity-related alterations, available data highlight the importance of considering gene–gene and gene–diet interactions. [J] . Julie. Lessard, André. Tchernof Clinical lipidology. . 2012,第5期

机译：脂肪形成与肥胖相关的差异已知脂肪细胞肥大和增生分别通过增加脂肪细胞的大小和数量来促进脂质在脂肪组织中的存储。脂肪形成是导致脂肪组织增生的过程。尽管已经有很多文献记载了贮库特异性差异和肥胖相关的脂肪细胞大小调节，但有关脂肪形成和脂肪组织增生的可用数据尚无定论。大多数研究支持在肥胖状态下减少脂肪形成。在大多数研究中，与来自内脏脂肪区室的脂肪细胞相比，皮下脂肪库的前脂肪细胞似乎对脂肪刺激更为敏感。许多研究支持这样的观点，即通过增生的脂肪组织扩张可以减少异位脂质过多和肥胖相关的并发症。在编码脂肪形成调节蛋白的基因中已经鉴定出几种遗传变异。尽管其中一些变异与肥胖症的表型和与肥胖有关的改变明显相关，但现有数据突出了考虑基因-基因和基因-饮食相互作用的重要性。
4. Proteomic Analysis of Age-Related Proteins in Mature Adipocytes Derived from Adipose Tissue of Obese Human Subjects [C] . Assim Alfadda, Hicham Benabdelkamel, Amr Moustafa, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2012

机译：肥胖人对象脂肪组织成熟脂肪细胞中年龄相关蛋白质的蛋白质组学分析
5. Determinants of llhydroxysteroid dehydrogenase type 1 activity and interleukin-6 in Polycystic Ovary Syndrome and the effects of metformin: a study of adipocyte function in PCOS [D] . Tsilchorozidou, Tasoula. 2007

机译：多囊卵巢综合征中Llhydroxysteroid脱氢酶1活性和白细胞介素-6的决定因素及二甲双胍的影响：PCOS中脂肪细胞功能的研究
6. Adipocytes like their progenitors contribute to inflammation of adipose tissues through promotion of Th-17 cells and activation of monocytes in obese subjects [O] . Marwa Chehimi, Maud Robert, Michel El Bechwaty, 2016

机译：与肥胖祖细胞一样脂肪细胞通过促进Th-17细胞的活化和单核细胞的活化促进脂肪组织的炎症。
7. OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects [O] . Moreno-Navarrete, José María, Ortega, Francisco J., Rodríguez-Hermosa, José-Ignacio, 2010

机译：脂肪细胞中的OCT1表达可能有助于肥胖受试者二甲双胍的作用增加。

OCT1 Expression in Adipocytes Could Contribute to Increased Metformin Action in Obese Subjects

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