Analysing recurrent hospitalisations in heart failure: a review of statistical methodology with application to CHARM-Preserved

摘要

BackgroundHeart failure is characterised by recurrent hospitalisations, but often only the first event is considered in clinical trial reports. In chronic diseases, such as heart failure, analysing all events gives a more complete picture of treatment benefit. We describe methods of analysing repeat hospitalisations, and illustrate their value in one major trial.