Role of CYP2E1 in Ethanol-Induced Oxidant Stress Fatty Liver and Hepatotoxicity

摘要

Background/AimsSeveral pathways contribute to mechanisms by which ethanol induces oxidant stress. While some studies support a role for cytochrome P450 2E1 (CYP2E1), others do not. There is a need to develop oral models of significant ethanol-induced liver injury and to evaluate the possible role of CYP2E1 in ethanol actions in such models.