Role of Glycogen Synthase Kinase-3 and tetraspanins in ethanol-induced henaviors

摘要

This invention pertains to the identification of genes that mediate an organisms behavioral response to consumption of alcohol and/or other substances of abuse. The genes include a tetraspanin Tsp42Ee gene or a homologue or analogue thereof, a tetraspanin Tsp42El gene or a homologue or analogue thereof, and a Glycogen Synthase Kinase-3 gene or a homologue or analogue thereof. The genes provide good targets to screen for agents that modulate an organism's response to consumption of alcohol and/or other substances of abuse.