Safety and Efficacy of a Novel Vaginal Anti-infective TOL-463 in the Treatment of Bacterial Vaginosis and Vulvovaginal Candidiasis: A Randomized Single-blind Phase 2 Controlled Trial

机译：新型阴道抗感染药TOL-463在治疗细菌性阴道病和念珠菌性念珠菌病中的安全性和有效性：随机单盲2期对照试验

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BackgroundBacterial vaginosis (BV) and vulvovaginal candidiasis (VVC) present serious reproductive health risks and management challenges, with poor control attributed to survival of treatment-resistant biofilm communities. Boric acid is used in various regimens for non-albicans VVC and recurrent BV. We investigated safety and efficacy of a novel boric acid–based vaginal anti-infective with enhanced antibiofilm activity (TOL-463) in treating BV and VVC.

机译：背景细菌性阴道病（BV）和念珠菌性外阴阴道炎（VVC）带来了严重的生殖健康风险和管理挑战，控制不力归因于耐药性生物膜群落的生存。硼酸用于非白色VVC和复发性BV的各种方案中。我们研究了一种新型的基于硼酸的阴道抗感染剂，具有增强的生物膜活性（TOL-463），用于治疗BV和VVC的安全性和有效性。

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期刊名称 Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
作者
Jeanne M Marrazzo; Julia C Dombrowski; Michael R Wierzbicki; Charlotte Perlowski; Angela Pontius; Dwyn Dithmer; Jane Schwebke;
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作者单位

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年(卷),期 -1(68),5
年度 -1
页码 803–809
总页数 7
原文格式 PDF
正文语种
中图分类免疫学;微生物学;病毒传染病;
关键词
TOL-463 boric acid bacterial vaginosis vulvovaginal candidiasis vaginal biofilm;

机译：TOL-463;硼酸;细菌性阴道病;念珠菌性阴道阴道炎;阴道生物膜;

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1. Safety and Efficacy of a Novel Vaginal Anti-infective, TOL-463, in the Treatment of Bacterial Vaginosis and Vulvovaginal Candidiasis: A Randomized, Single-blind, Phase 2, Controlled Trial [J] . Marrazzo Jeanne M., Dombrowski Julia C., Wierzbicki Michael R., Clinical infectious diseases . 2019,第5期

机译：新型阴道抗感染性的安全性和有效性，Tol-463，治疗细菌性阴道病和外阴念珠菌病：随机，单盲，第2期，受控试验
2. A comparison of dequalinium chloride vaginal tablets (fluomizin?) and clindamycin vaginal cream in the treatment of bacterial vaginosis: A single-blind, randomized clinical trial of efficacy and safety fluomizin study group [J] . WeissenbacherE.R., DondersG., UnzeitigV., Gynecologic and obstetric investigation . 2012,第1期

机译：氯喹定阴道片（fluomizin？）和克林霉素阴道乳膏治疗细菌性阴道病的比较：有效性和安全性氟米嗪研究组的单盲，随机临床试验
3. A Phase 3, Multicenter, Randomized, Double-Blind, Vehicle-Controlled Study Evaluating the Safety and Efficacy of Metronidazole Vaginal Gel 1.3% in the Treatment of Bacterial Vaginosis [J] . Schwebke Jane R., Marrazzo Jeanne, Beelen Andrew P., Sexually transmitted diseases . 2015,第7期

机译：一项三期，多中心，随机，双盲，载体对照研究，评估1.3％甲硝唑阴道凝胶治疗细菌性阴道病的安全性和有效性
4. Adding Potassium and Calcium to the dietary salt as a hypertension-preventive approach in adolescents with higher blood pressure and their family members: a random single-blind controlled trial [C] . Jianjun Mu, Zhiquan Liu, Xianglin Xu, “中、美食盐与健康”国际研讨会（International Workshop of Dietary Sodium and Human Health in China and the United States） . 2008

机译：在高血压的青少年及其家庭成员中，作为预防高血压的方法，向饮食盐中添加钾和钙：一项随机的单盲对照试验
5. Bacterial vaginosis: A randomized controlled trial to prevent recurrence. [D] . Bukusi, Elizabeth Anne. 2006

机译：细菌性阴道病：一项防止复发的随机对照试验。
6. Efficacy and safety of ultra-low dose 0.005 estriol vaginal gel for the treatment of vulvovaginal atrophy in postmenopausal women with early breast cancer treated with nonsteroidal aromatase inhibitors: a phase II randomized double-blind placebo-controlled trial [O] . Angelica Lindén Hirschberg, Pedro Sánchez-Rovira, Jesús Presa-Lorite, -1

机译：非甾体类芳香化酶抑制剂治疗的绝经后早期绝经后妇女外阴阴道萎缩的超低剂量0.005％雌三醇阴道凝胶的疗效和安全性：II期随机双盲安慰剂对照试验
7. A comparison of dequalinium chloride vaginal tablets (Fluomizin®) and clindamycin vaginal cream in the treatment of bacterial vaginosis: a single-blind, randomized clinical trial of efficacy and safety [O] . Weissenbacher, Ernst Rainer, Donders, Gilbert, Unzeitig, Vit, 2012

机译：氯喹定阴道片（Fluomizin®）和克林霉素阴道乳膏在细菌性阴道病治疗中的比较：有效性和安全性的单盲，随机临床试验

Safety and Efficacy of a Novel Vaginal Anti-infective TOL-463 in the Treatment of Bacterial Vaginosis and Vulvovaginal Candidiasis: A Randomized Single-blind Phase 2 Controlled Trial

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