Phase 2a Safety Pharmacokinetics and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women

机译：Dapivirine阴道环在美国绝经后妇女中的2a期安全性药代动力学和可接受性

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BackgroundPostmenopausal women have unique sociobiological human immunodeficiency virus (HIV) risks. We evaluated the safety, pharmacokinetics, and acceptability of a microbicide dapivirine (DPV) vaginal ring (VR) versus placebo in postmenopausal women.

机译：背景绝经后妇女具有独特的社会生物学人类免疫缺陷病毒（HIV）风险。我们评估了绝经后妇女使用杀菌剂达比韦林（DPV）阴道环（VR）与安慰剂的安全性，药代动力学和可接受性。

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期刊名称 Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
作者
Beatrice A Chen; Jingyang Zhang; Holly M Gundacker; Craig W Hendrix; Craig J Hoesley; Robert A Salata; Charlene S Dezzutti; Ariane van der Straten; Wayne B Hall; Cindy E Jacobson; Sherri Johnson; Ian McGowan; Annalene M Nel; Lydia Soto-Torres; Mark A Marzinke; B A Chen; C J Hoesley; B A Chen; R A Salata;
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作者单位

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年(卷),期 -1(68),7
年度 -1
页码 1144–1151
总页数 8
原文格式 PDF
正文语种
中图分类免疫学;微生物学;病毒传染病;
关键词
microbicide pre-exposure prophylaxis dapivirine vaginal rings menopause;

机译：杀菌剂;暴露前预防;达匹韦林;阴道环;更年期;

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专利

1. Phase 2a Safety, Pharmacokinetics, and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women [J] . Chen Beatrice A., Zhang Jingyang, Gundacker Holly M., Clinical infectious diseases . 2019,第7期

机译：第2A期安全性，药代动力学和美国绝经后妇女的Dapiviine阴道戒指的可接受性
2. A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film [J] . Bunge Katherine E., Dezzutti Charlene S., Rohan Lisa C., JAIDS: Journal of acquired immune deficiency syndromes . 2016,第5期

机译：评估新型Dapivirine阴道膜的安全性，可接受性，药代动力学和药效学的1期试验
3. A safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women [J] . NelA., HaazenW., NuttallJ., AIDS . 2014,第10期

机译：评估健康女性阴道环中达匹韦林递送的安全性和药代动力学试验
4. Preclinical stability evaluation of dapivirine and maraviroc release in vitro from combination silicone elastomer vaginal rings [C] . Susan M. Fetherston, Peter Boyd, Marcella McBride, Annual meeting exposition of the Controlled Release Society . 2010

机译：联合硅氧烷弹性体阴道环体外释放达匹韦林和马拉维罗的临床前稳定性评价
5. A phase Ib study of safety and pharmacokinetics of trastuzumab emtansine and pertuzumab in Japanese patients with HER2-positive metastatic breast cancer [D] . NOGUCHI, Emi 2019

机译：Ib期研究曲妥珠单抗氨丹宁和帕妥珠单抗在日本HER2阳性转移性乳腺癌患者中的安全性和药代动力学
6. A Phase 1 trial to assess the safety acceptability pharmacokinetics and pharmacodynamics of a novel dapivirine vaginal film [O] . Authors: Katherine E. Bunge, Charlene S. Dezzutti, Lisa C. Rohan, -1

机译：一项评估新型dapivirine阴道膜安全性可接受性药代动力学和药效学的1期试验
7. A Phase 1 Trial to Assess the Safety, Acceptability, Pharmacokinetics, and Pharmacodynamics of a Novel Dapivirine Vaginal Film [O] . Katherine E. Bunge, Charlene S. Dezzutti, Lisa C. Rohan, 2016

机译：1期试验，以评估新型达佩里林阴道薄膜的安全性，可接受性，药代动力学和药效学

Phase 2a Safety Pharmacokinetics and Acceptability of Dapivirine Vaginal Rings in US Postmenopausal Women

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