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Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes

机译：豚鼠心室肌细胞中Ca2 + /钙调蛋白和Ca2 + /钙调蛋白依赖性蛋白激酶II对Na +通道的调节

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AimsCalmodulin (CaM) regulates Na⁺ channel gating through binding to an IQ-like motif in the C-terminus. Ca²⁺/CaM-dependent protein kinase II (CaMKII) regulates Ca²⁺ handling, and chronic overactivity of CaMKII is associated with left ventricular hypertrophy and dysfunction and lethal arrhythmias. However, the acute effects of Ca²⁺/CaM and CaMKII on cardiac Na⁺ channels are not fully understood.

机译：AimsCalmodulin（CaM）通过与C端的IQ样基序结合来调节Na ^{+ 通道门控。 Ca ^{2 + / CaM依赖性蛋白激酶II（CaMKII）调节Ca ^{2 + 的处理，并且CaMKII的长期过度活跃与左心室肥大，功能障碍和致死性心律失常有关。然而，Ca ^{2 + / CaM和CaMKII对心脏Na ^{+ 通道的急性作用尚不完全清楚。}}}}}

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期刊名称 Cardiovascular Research
作者
Takeshi Aiba; Geoffrey G. Hesketh; Ting Liu; Rachael Carlisle; Maria Celeste Villa-Abrille; Brian ORourke; Fadi G. Akar; Gordon F. Tomaselli;
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作者单位

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年(卷),期 -1(85),3
年度 -1
页码 454–463
总页数 10
原文格式 PDF
正文语种
中图分类心血管疾病;
关键词
Na-channel Calcium Calmodulin Casup2+/sup/CaM-dependent protein kinase II;

机译：Na通道;钙;钙调蛋白;Ca sup 2 + / sup / CaM依赖性蛋白激酶II;

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专利

1. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes. [J] . Aiba T, Hesketh GG, Liu Cardiovascular Research . 2010,第3期

机译：豚鼠心室肌细胞中Ca2 + /钙调蛋白和Ca2 + /钙调蛋白依赖性蛋白激酶II对Na +通道的调节。
2. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes† [J] . Takeshi Aiba, Geoffrey G. Hesketh, Ting Liu, Cardiovascular Research . 2010,第3期

机译：Ca 2 + /钙调蛋白和Ca 2 + /钙调蛋白依赖性蛋白激酶II调节Na + 通道在豚鼠心室肌细胞中的作用>†
3. Ca2+/calmodulin-dependent protein kinase ii-based regulation of voltage-gated na+ channel in cardiac disease [J] . KovalO.M., SnyderJ.S., WolfR.M., Circulation: An Official Journal of the American Heart Association . 2012,第17期

机译：基于Ca2 + /钙调蛋白依赖性蛋白激酶II的心脏疾病中电压门控Na +通道的调节
4. Localization of activated Ca2+/calmodulin-dependent protein kinase II within a spine: modeling and computer simulation [C] . Kazuhisa Ichikawa Computational Neuroscience Meeting . 2004

机译：活化的Ca2 + /钙调蛋白依赖性蛋白激酶II的定位在脊柱内：建模和计算机仿真
5. Mitochondrial Ca2+/Calmodulin-Dependent Kinase II (CaMKII) Regulates Smooth Muscle Cell Migration and Neointimal Formation via Mitochondrial Ca2+ Uptake and Mobility [D] . Nguyen, Emily Kim. 2019

机译：线粒体CA2 + /钙调霉素依赖性激酶II（CAMKII）通过线粒体CA2 +摄取和移动性调节平滑肌细胞迁移和新内膜形成
6. Integrative Cardiovascular Physiology and Pathophysiology: Ca2+/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+ current Ca2+ cycling and excitability: a mathematical modeling study [O] . Birce Onal, Daniel Gratz, Thomas J. Hund -1

机译：综合心血管生理学和病理生理学：心房肌细胞晚Na +电流Ca2 +循环和兴奋性的Ca2 + /钙调蛋白依赖性激酶II依赖性调节：数学建模研究
7. Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes† [O] . Aiba, Takeshi, Hesketh, Geoffrey G., Liu, Ting, 2009

机译：Ca2 + /钙调蛋白和Ca2 + /钙调蛋白依赖性蛋白激酶II对豚鼠心室肌细胞的Na +通道调节†

Na+ channel regulation by Ca2+/calmodulin and Ca2+/calmodulin-dependent protein kinase II in guinea-pig ventricular myocytes

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