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Pointwise nonparametric maximum likelihood estimator of stochastically ordered survivor functions

机译:随机排序的幸存函数的逐点非参数最大似然估计

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摘要

In this paper, we consider estimation of survivor functions from groups of observations with right-censored data when the groups are subject to a stochastic ordering constraint. Many methods and algorithms have been proposed to estimate distribution functions under such restrictions, but none have completely satisfactory properties when the observations are censored. We propose a pointwise constrained nonparametric maximum likelihood estimator, which is defined at each time t by the estimates of the survivor functions subject to constraints applied at time t only. We also propose an efficient method to obtain the estimator. The estimator of each constrained survivor function is shown to be nonincreasing in t, and its consistency and asymptotic distribution are established. A simulation study suggests better small and large sample properties than for alternative estimators. An example using prostate cancer data illustrates the method.
机译:在本文中,当分组受到随机排序约束时,我们考虑从具有右删失数据的观察组估计幸存者功能。已经提出了许多方法和算法来估计在这种限制下的分布函数,但是当检查被观察时,没有一种方法具有完全令人满意的特性。我们提出了一个逐点约束的非参数最大似然估计器,该估计器在每个时间t都由仅在时间t施加约束的幸存者函数的估计来定义。我们还提出了一种有效的方法来获取估计量。每个受约束的幸存者函数的估计量在t上不增加,并且证明了其一致性和渐近分布。仿真研究表明,与其他估计量相比,大小样本的属性更好。使用前列腺癌数据的示例说明了该方法。

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