Hearing Loss after Round Window Surgery in Mice is due to Middle Ear Effusion

摘要

Background:Delivery of therapeutic agents directly through the round window (RW) offers promise for treating sensorineural hearing loss. However, hearing loss can result from the surgical approach itself, and the reasons for this are poorly understood. We examined the hearing loss following the three major steps involved with the RW approach to access the mouse cochlea: bullostomy, RW puncture, and RW injection.