Sexual dimorphism in the blood pressure response to angiotensin II in mice after angiotensin converting enzyme bloackade

摘要

BackgroundThe incidence of hypertension and progression of renal disease are greater in men than women. Data suggests that there is a dimorphic response to angiotensin II (Ang II) in rats, with male rats exhibiting a greater increase in mean arterial pressure (MAP) than females. However, during endogenous renin angiotensin systemblockade with angiotensin-converting enzyme (ACE) inhibition, female rats have a greater MAP response to Ang II. We tested weather female mice exhibit a greater MAP response to chronic Ang II during ACE inhibtion.