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Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy

机译：胆碱代谢产物水平升高是BRCA1突变小鼠乳腺肿瘤中多西他赛治疗反应的早期标志物：离体质子磁共振波谱评估

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BackgroundDocetaxel is one of the most frequently used drugs to treat breast cancer. However, resistance or incomplete response to docetaxel is a major challenge. The aim of this study was to utilize MR metabolomics to identify potential biomarkers of docetaxel resistance in a mouse model for BRCA1-mutated breast cancer.

机译：背景多西他赛是治疗乳腺癌的最常用药物之一。但是，对多西紫杉醇的耐药性或不完全应答是一个重大挑战。这项研究的目的是利用MR代谢组学在BRCA1突变的乳腺癌小鼠模型中识别多西他赛耐药的潜在生物标记。

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期刊名称 Journal of Translational Medicine
作者
Jack JA van Asten; Riyas Vettukattil; Tessa Buckle; Sven Rottenberg; Fijs van Leeuwen; Tone F Bathen; Arend Heerschap;
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年(卷),期 2015(13),-1
年度 2015
页码 114
总页数 8
原文格式 PDF
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中图分类医学史 ;
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1. Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy [J] . Jack JA van Asten, Riyas Vettukattil, Tessa Buckle, Journal of Translational Medicine . 2015 ,第1期

机译：胆碱代谢物水平升高是BRCA1突变的小鼠乳腺肿瘤中多西他赛治疗反应的早期标志物：离体质子磁共振波谱评估
2. Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NAA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study [J] . Neven Henigsberg, Helena ?arac, Marko Rado?, Frontiers in Psychiatry . 2017 ,第1期

机译：维持疗法下胆碱含量较低的代谢物/肌酸（Cr）的升高和后外侧前额叶皮层中NAA / Cr水平的维持与抑郁发作的复发相关：质子磁共振波谱回顾性队列研究
3. Role of proton magnetic resonance spectroscopy in the diagnosis of gliomatosis cerebri: a unique pattern of normal choline but elevated Myo-inositol metabolite levels. [J] . Mohana Borges AV, Imbesi SG, Dietrich R, Journal of computer assisted tomography . 2004 ,第1期

机译：质子磁共振波谱在脑胶质瘤病诊断中的作用：正常胆碱的独特模式，但肌醇代谢产物水平升高。
4. T2-relaxation time measurement of metabolite peak in gastric tissue using ex vivo proton magnetic resonance spectroscopy imaging [C] . Choi K.S., Park C.S., Kim S.H., Enterprise networking and Computing in Healthcare Industry, 2005. HEALTHCOM 2005. Proceedings of 7th International Workshop on . 2005

机译：利用离体质子磁共振波谱成像测量胃组织中代谢物峰的T2弛豫时间
5. From mouse mammary tumor model to new therapeutic method---Mammary tumor development in BALB/c-Trp53+/- mice and magnetic nanoparticle induced heating for cancer treatment. [D] . Yan, Haoheng. 2010

机译：从小鼠乳腺肿瘤模型到新的治疗方法-BALB / c-Trp53 +/-小鼠的乳腺肿瘤发展以及磁性纳米粒子诱导的加热治疗癌症。
6. Lower Choline-Containing Metabolites/Creatine (Cr) Rise and Failure to Sustain NAA/Cr Levels in the Dorsolateral Prefrontal Cortex Are Associated with Depressive Episode Recurrence under Maintenance Therapy: A Proton Magnetic Resonance Spectroscopy Retrospective Cohort Study [O] . Neven Henigsberg, Helena Šarac, Marko Radoš, 2017

机译：维持疗法下胆碱含量较低的代谢物/肌酸（Cr）的升高和维持后外侧前额叶皮层中NAA / Cr水平的维持与抑郁发作的复发有关：质子磁共振波谱回顾性队列研究
7. Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy. [O] . van Asten Jack J A, Vettukattil Riyas, Buckle Tessa, 2015

机译：胆碱代谢物水平升高是BRCA1突变的小鼠乳腺肿瘤中多西他赛治疗反应的早期标志物：通过离体质子磁共振波谱进行评估。

Increased levels of choline metabolites are an early marker of docetaxel treatment response in BRCA1-mutated mouse mammary tumors: an assessment by ex vivo proton magnetic resonance spectroscopy

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