SAR110894 a potent histamine H3-receptor antagonist displays disease-modifying activity in a transgenic mouse model of tauopathy

摘要

IntroductionTau hyperphosphorylation and neurofibrillary tangles are histopathologic hallmarks of tauopathies. Histamine H3-receptor antagonists have been proposed to reduce tau hyperphosphorylation in preclinical models.