Detection of bacterial DNA from central venous catheter removed from patients by next generation sequencing: a preliminary clinical study

摘要

BackgroundCatheter-related infection (CRI) is one of the serious challenges in clinical practice. This preliminary clinical study aimed to examine whether next-generation sequencing (NGS) targeting 16S rDNA, which was PCR-amplified directly from the tip of a central venous catheter (CVC), can be used to identify causative pathogens in CRI, compared to the culture method.