AB012. Impact of down-regulated SK3 expressions in Hirschsprung’s disease patients following pull-through surgery

摘要

BackgroundSome Hirschsprung’s disease (HSCR) patients showed persistent bowel symptoms following an appropriately pull-through procedure. The mechanism is presumed to be down-regulated small-conductance calcium-activated potassium channel 3 (SK3) expressions in the HSCR ganglionic intestines. We aimed to investigate the SK3 expressions impact in HSCR patients after a properly pull-through surgery in Indonesian population, a genetically distinct group within Asia.