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Measurement of Voriconazole Activity against Candida albicans C. glabrata and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography

机译：使用高效液相色谱法验证的杀伤时间法测定伏立康唑对白色念珠菌光滑念珠菌和副念珠菌分离株的活性

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We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.

机译：我们开发了一种高效液相色谱（HPLC）测定法，以验证伏立康唑针对白色念珠菌，光滑念珠菌和副念珠菌分离株的杀灭时间和抑菌后效果（PAFE）实验。伏立康唑具有延长的抑菌活性，但在人血清中可达到的浓度下没有PAFE。 HPLC证实实验是在所需的伏立康唑稳态浓度下进行的。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
Yanjun Li; M. Hong Nguyen; Hartmut Derendorf; Shaoji Cheng; Cornelius J. Clancy;
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作者单位

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年(卷),期 2007(51),8
年度 2007
页码 2985–2987
总页数 3
原文格式 PDF
正文语种
中图分类药学;微生物学;
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专利

1. Measurement of voriconazole activity against Candida albicans, C. glabrata, and C. parapsilosis isolates using time-kill methods validated by high-performance liquid chromatography. [J] . Li Y, Nguyen MH, Derendorf H, Antimicrobial agents and chemotherapy. . 2007,第8期

机译：使用经高效液相色谱验证的时间杀灭方法，测定伏立康唑对白色念珠菌，光滑念珠菌和副念珠菌分离物的活性。
2. Anidulafungin is fungicidal and exerts a variety of postantifungal effects against Candida albicans, C. glabrata, C. parapsilosis, and C. krusei isolates. [J] . Nguyen KT, Ta P, Hoang BT Antimicrobial agents and chemotherapy. . 2009,第8期

机译：Anidulafungin具有杀真菌作用，并且对白色念珠菌，光滑念珠菌，副念珠菌和克鲁斯梭菌分离株具有多种杀真菌作用。
3. Antifungal Activity of Organic and Aqueous Extractions in Plakobranchus ocellatus (Gastropoda: Sacoglossa) against Candida albicans , C. parapsilosis and C. glabrata [J] . Shahram Oliaei, Eelia Etemadi- Deylami, Behrooz Heidari, Microbiology Journal . 2015,第1期

机译：斜纹小球藻（Gastropoda：Sacoglossa）中的有机和水提取物对白色念珠菌，副念珠菌和光滑念珠菌的抗真菌活性。
4. The effect of propolis honey candy on C. Albicans and clinical isolate biofilms viability (in-vitro) [C] . Sri Angky Soekanto, Endang W. Bachtiar, Amatul Firdaus Ramadhan, International Symposium of Biomedical Engineering . 2018

机译：蜂胶蜂蜜糖果对C. albicans和临床分离生物膜活力的影响（体外）
5. Method development and validation for the separation of the enantiomers of miconazole raw material using high-performance liquid chromatography [D] . Al Shimmry, Raad K. 2018

机译：用高效液相色谱法分离咪康唑原料对映体分离的方法的开发和验证
6. In Vitro Activity of Ibrexafungerp (SCY-078) against Candida auris Isolates as Determined by EUCAST Methodology and Comparison with Activity against C. albicans and C. glabrata and with the Activities of Six Comparator Agents [O] . Maiken Cavling Arendrup, Karin Meinike Jørgensen, Rasmus Krøger Hare, 2020

机译：Ibrexafungerp（Scy-078）对念珠菌的体外活性以果树方法测定如果糖化方法确定并与C. albicans和C.Glabrata的活性进行比较以及六个比较剂的活动
7. Measurement of Voriconazole Activity against Candida albicans, C. glabrata, and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography▿ [O] . Li, Yanjun, Nguyen, M. Hong, Derendorf, Hartmut, 2007

机译：使用高效液相色谱法验证的杀伤时间法测定伏立康唑对白色念珠菌，光滑念珠菌和副念珠菌分离株的活性

Measurement of Voriconazole Activity against Candida albicans C. glabrata and C. parapsilosis Isolates Using Time-Kill Methods Validated by High-Performance Liquid Chromatography

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