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Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities

机译：具有抗乙肝病毒活性的新型无环核苷膦酸酯类似物

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摘要

Novel acyclic nucleoside phosphonates with a pyrimidine base preferentially containing an amino group at C-2 and C-4 and a 2-(phosphonomethoxy)ethoxy or (R)-2-(phosphonomethoxy)propoxy group at C-6 selectively inhibit the replication of wild-type and lamivudine-resistant hepatitis B viruses. The activity of the most potent compounds was comparable to that of adefovir.

机译：新型的无环核苷膦酸酯，其嘧啶碱基优先在C-2和C-4处含有氨基，在C-6处具有2-（膦甲氧基）乙氧基或（R）-2-（膦甲氧基）丙氧基，选择性地抑制野生型和抗拉米夫定的乙型肝炎病毒。最有效的化合物的活性与阿德福韦相当。

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期刊名称 Antimicrobial Agents and Chemotherapy
作者
C. Ying; A. Holý; D. Hocková; Z. Havlas; E. De Clercq; J. Neyts;
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作者单位

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年(卷),期 2005(49),3
年度 2005
页码 1177–1180
总页数 4
原文格式 PDF
正文语种
中图分类药学 ; 微生物学 ;
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专利

1. Novel acyclic nucleoside phosphonate analogues with potent anti-hepatitis B virus activities. [J] . Ying C, Holy A, Hockova D, Antimicrobial agents and chemotherapy. . 2005 ,第3期

机译：具有有效的抗乙型肝炎病毒活性的新型无环核苷膦酸酯类似物。
2. Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of the 6-oxopurine phosphoribosyltransferases and have antimalarial activity [J] . Dianne Keough, Petr ?pa?ek, Dana Hocková, Malaria Journal . 2014 ,第S1期

机译：含有第二个膦酸酯基的无环核苷膦酸酯是6-氧嘌呤磷酸核糖基转移酶的有效抑制剂，并具有抗疟疾活性
3. Acyclic nucleoside phosphonates containing a second phosphonate group are potent inhibitors of 6-oxopurine phosphoribosyltransferases and have antimalarial activity [J] . Keough D.T., ?pa?ek P., Hocková D., Journal of Medicinal Chemistry . 2013 ,第6期

机译：含有第二个膦酸酯基团的无环核苷膦酸酯是6-氧嘌呤磷酸核糖基转移酶的有效抑制剂，并具有抗疟活性
4. Acyclic nucleoside phosphonates as a new class of anti-malarial compounds: Inhibition of Plasmodium falciparum hypoxanthine-guahine-xanthine phosphoribosyltransferase by 9-2-(2-phosphonoethoxy)ethyl-purines and their branched derivatives [C] . Dana Hockova, Antonin Holy, Dianne T. Keough European Symposium on Organic Chemistry . 2009

机译：环状核苷膦酸盐作为一种新的抗疟疾化合物：抑制疟原虫脱氧黄嘌呤 - 黄嘌呤 - 黄嘌呤磷酰基转移酶的抑制作用9- 2-（2-膦酰基乙氧基）乙基 - 杂物和其支化衍生物
5. Synthesis of Acyclic Flexible Nucleoside Analogues against Emerging and Reemerging Infectious Diseases [D] . Yates, Mary Kendall. 2019

机译：对新兴和再生传染病的无环柔性核苷类似物的合成
6. Differential antiherpesvirus and antiretrovirus effects of the (S) and (R) enantiomers of acyclic nucleoside phosphonates: potent and selective in vitro and in vivo antiretrovirus activities of (R)-9-(2-phosphonomethoxypropyl)-26-diaminopurine. [O] . J Balzarini, A Holy, J Jindrich, 1993

机译：无环核苷膦酸酯的（S）和（R）对映异构体的抗疱疹病毒和抗逆转录病毒作用的差异：（R）-9-（2-膦酰甲氧基丙基）-26-二氨基嘌呤的体外和体内抗逆转录病毒活性强和选择性。
7. Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities [O] . Ying, C., Holý, A., Hocková, D., 2005

机译：具有抗乙肝病毒活性的新型无环核苷膦酸酯类似物
8. Synthesis of Nucleoside Analogues with Potential Antiviral Activity against Negative Strand RNA Virus Targets. [R] . Walker, R. T. 1989

机译：具有抗负链RNa病毒靶标的潜在抗病毒活性的核苷类似物的合成。

Novel Acyclic Nucleoside Phosphonate Analogues with Potent Anti-Hepatitis B Virus Activities

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