>Aims: To evaluate the pulmonary arterial pressure in children with nephrotic syndrome (NS). >Methods: Doppler echocardiography was performed in 40 children with NS (aged 1.5–13 years) at NS onset (n = 28) or relapse (n = 12), and 40 normal controls. Pulmonary pressure was estimated by: (1) measuring the systolic transtricuspid gradient from tricuspid regurgitation; and (2) measuring the time to peak velocity of pulmonary flow. >Results: Thirty five of the 40 patients with NS had measurable tricuspid regurgitation with a pulmonary systolic pressure ranging from 21 to 48 mm Hg. Pulmonary systolic pressure was >40 mm Hg in seven patients. The pulmonary time to peak velocity was shortened and the ratio of time to peak velocity and right ventricular ejection time decreased compared with controls. The patients with increased pulmonary pressure had a longer time since onset of NS. One patient developed thrombus in the inferior vena cava during hospitalisation. >Conclusion: Pulmonary arterial pressure was increased in children with NS. Further work is needed to evaluate the aetiology and clinical implications of this abnormality.
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机译：>目的：评估肾病综合征（NS）儿童的肺动脉压。 >方法：对40例NS发作（n = 28）或复发（n = 12）的NS（1.5-13岁）儿童和40例正常对照进行了多普勒超声心动图检查。通过以下方法估算肺压：（1）测量三尖瓣关闭不全引起的收缩期经皮三尖瓣梯度； （2）测量达到肺血流峰值速度的时间。 >结果：40例NS患者中有35例具有可测量的三尖瓣关闭不全，肺动脉收缩压范围为21至48 mm Hg。 7例患者的肺收缩压> 40 mm Hg。与对照组相比，缩短了肺部达到峰值速度的时间，缩短了达到峰值速度的时间与右心室射血时间的比率。自NS发作以来，肺动脉高压患者的时间更长。一名患者在住院期间下腔静脉出现血栓。 >结论： NS患儿的肺动脉压升高。需要进一步的工作来评估这种异常的病因和临床意义。
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