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Pathophysiology and Management of Arrhythmias Associated with Atrial Septal Defect and Patent Foramen Ovale

机译:与房间隔缺损和卵圆孔未闭相关的心律失常的病理生理学和处理

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摘要

Atrial septal defects (ASDs) are among the most common of congenital heart defects and are frequently associated with atrial arrhythmias. Atrial and ventricular geometrical remodelling secondary to the intracardiac shunt promotes evolution of the electrical substrate, predisposing the patient to atrial fibrillation and other arrhythmias. Closure of an ASD reduces the immediate and long-term prevalence of atrial arrhythmias, but the evidence suggests that patients remain at an increased long-term risk in comparison with the normal population. The closure technique itself and its timing impacts future arrhythmia risk profile while subsequent transseptal access following surgical or device closure is complicated. Newer techniques combined with increased experience will help to alleviate some of the difficulties associated with optimal management of arrhythmias in these patients.
机译:房间隔缺损(ASD)是先天性心脏缺损中最常见的一种,经常与房性心律不齐相关。心内分流继发的心房和心室几何重塑可促进电底物的进化,使患者容易发生房颤和其他心律不齐。关闭ASD可降低房性心律失常的即时和长期患病率,但有证据表明,与正常人群相比,患者的长期风险仍在增加。闭合技术本身及其时机会影响未来的心律失常风险,而在手术或器械闭合后,随后的经隔进入较复杂。较新的技术和增加的经验将有助于减轻与这些患者心律不齐的最佳管理相关的一些困难。

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