Hepatocyte-specific Hmgb1 Deletion

摘要

High mobility group box 1 (HMGB1) plays a key role in human health and disease. Currently, three different labs in the USA use Cre-lox technology to create mice with a hepatocyte-specific Hmgb1 deletion (HMGB1-HC-KO mice) by backcrossing Hmgb1 ^flox/^flox mice to Alb-Cre mice. This mouse strain has a different phenotype following exposure to several stressors.