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Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin paclitaxel or doxorubicin

机译：选择对顺铂紫杉醇或阿霉素具有抗性的卵巢癌细胞的基因表达和途径分析

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BackgroundResistance to current chemotherapeutic agents is a major cause of therapy failure in ovarian cancer patients, but the exact mechanisms leading to the development of drug resistance remain unclear.

机译：背景技术目前对化疗药物的耐药性是卵巢癌患者治疗失败的主要原因，但导致耐药性发展的确切机制仍不清楚。

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期刊名称 Journal of Ovarian Research
作者
Cheryl A Sherman-Baust; Kevin G Becker; William H Wood III; Yongqing Zhang; Patrice J Morin;
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年(卷),期 2011(4),-1
年度 2011
页码 21
总页数 11
原文格式 PDF
正文语种
中图分类生理学;
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入库时间 2022-08-17 11:49:38

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1. Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin [J] . Cheryl A Sherman-Baust, Kevin G Becker, William H Wood III, Journal of Ovarian Research . 2011,第1期

机译：选择对顺铂，紫杉醇或阿霉素具有抗性的卵巢癌细胞的基因表达和途径分析
2. ings identical to those of the primary tumor. Chemosensitivity test showed that paclitaxel induced the highest chemosensitivity index. In microarray analysis, 2,520 probes were differently expressed, compared to human ovarian surface epithelial cells (HOSEs). In SYBR Green real-time PCR, the expression of E2F2 (P = 0.040) and CRABP2 genes (P = 0.030) was significantly higher in the ovarian cancer cell lines than in HOSEs. Furthermore, proteomic analysis showed that expression of 28 spots was sig [J] . Diabetes/metabolism research and reviews . 2009,第6期

机译：与原发肿瘤相同。化学敏感性试验表明紫杉醇诱导了最高的化学敏感性指数。在微阵列分析中，与人卵巢表面上皮细胞（HOSE）相比，表达了2520个探针。在SYBR Green实时PCR中，卵巢癌细胞系中E2F2（P = 0.040）和CRABP2基因（P = 0.030）的表达明显高于HOSE。此外，蛋白质组学分析显示28个斑点的信号
3. Identification of Cisplatin-Resistance Associated Genes through Proteomic Analysis of Human Ovarian Cancer Cells and a Cisplatin-resistant Subline [J] . Jing Zhou, Yue-Hua Wei, Mei-Yan Liao, Asian Pacific Journal of Cancer Prevention . 2012,第12期

机译：通过人卵巢癌细胞和顺铂耐血糖蛋白质组学分析鉴定顺铂抵抗相关基因
4. Breast Cancer Cells Response to the Antineoplastic Agents Cisplatin, Carboplatin, and Doxorubicin at the mRNA Expression Levels of Distinct Apoptosis-Related Genes, Including the New Member, BCL2L12 [C] . HELLINIDA THOMADAKI, ANDREAS SCORILAS Meeting on Cell Signaling World: Signal Transduction Pathways as Therapeutic Targets . 2007

机译：在不同凋亡相关基因（包括新成员BCL2L12）的mRNA表达水平上，乳腺癌细胞对抗肿瘤药顺铂，卡铂和阿霉素的反应
5. E3 Ligase Identified by Differential Display (EDD) Enhances Cell Survival and Cisplatin Resistance in Epithelial Ovarian Cancer and Oral Squamous Cell Carcinoma. [D] . Bradley, Amber Thompson. 2014

机译：通过差异显示（EDD）鉴定的E3连接酶可增强上皮性卵巢癌和口腔鳞状细胞癌的细胞存活率和顺铂耐药性。
6. Paclitaxel and SN‐38 Overcome Cisplatin Resistance of Ovarian Cancer Cell Lines by Down‐regulating the Influx and Efflux System of Cisplatin [O] . Yuuki Komuro, Yasuhiro Udagawa, Nobuyuki Susumu, 2001

机译：紫杉醇和SN‐38通过下调顺铂流入和流出系统来克服卵巢癌细胞系的顺铂耐药性
7. Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin, paclitaxel, or doxorubicin [O] . Cheryl A Sherman-Baust, Kevin G Becker, William H Wood III, 2011

机译：选择对顺铂，紫杉醇或阿霉素具有抗性的卵巢癌细胞的基因表达和途径分析

Gene expression and pathway analysis of ovarian cancer cells selected for resistance to cisplatin paclitaxel or doxorubicin

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