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LncRNA XIST promotes extracellular matrix synthesis proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury

机译：LncRNA XIST通过靶向热损伤后人皮肤成纤维细胞中的miR-29b-3p / COL1A1来促进细胞外基质合成增殖和迁移

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摘要

BackgroundLong noncoding RNAs (lncRNAs) have been reported to be associated with dermis process during burn wound healing. This study aimed to investigate the role of lncRNA X-inactive specific transcript (XIST) in human skin fibroblasts (HSF) and extracellular matrix (ECM) as well as the regulatory network of XIST/microRNA-29b-3p (miR-29b-3p)/collagen 1 alpha 1 (COL1A1).

机译：背景技术据报道，长的非编码RNA（lncRNA）与烧伤创面愈合过程中的真皮过程有关。这项研究旨在调查lncRNA X失活特异性转录本（XIST）在人皮肤成纤维细胞（HSF）和细胞外基质（ECM）以及XIST / microRNA-29b-3p（miR-29b-3p ）/胶原蛋白1 alpha 1（COL1A1）。

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期刊名称 Biological Research
作者
Wei Cao; Youping Feng;
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作者单位

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年(卷),期 2019(52),-1
年度 2019
页码 52
总页数 11
原文格式 PDF
正文语种
中图分类生物学;
关键词
Wound healing Thermal injury XIST miR-29b-3p COL1A1;

机译：伤口愈合;热损伤;XIST;miR-29b-3p;COL1A1;

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专利

1. lncRNA TUG1 Promotes Cell Proliferation, Migration, and Invasion in Hepatocellular Carcinoma via Regulating miR-29c-3p/ COL1A1 Axis [J] . Wei Zhao, Xue Jiang, Shuxia Yang Cancer Management and Research . 2020,第4期

机译：LNCRNA Tug1通过调节miR-29c-3p / col1a1轴来促进肝细胞癌中的细胞增殖，迁移和侵袭
2. LncRNA NR_003923 promotes cell proliferation, migration, fibrosis, and autophagy via the miR-760/miR-215-3p/IL22RA1 axis in human Tenon’s capsule fibroblasts [J] . Yang Zhao, Feng Zhang, Zheng Pan, Cell death & disease. . 2019,第8期

机译：LNCRNA NR_003923通过MIR-760 / MIR-215-3P / IL22ARA1轴促进细胞增殖，迁移，纤维化和自噬，在人榫胶囊成纤维细胞中
3. Role of XIST/miR‐29a/LIN28A pathway in denatured dermis and human skin fibroblasts (HSFs) after thermal injury [J] . Guo Le, Huang Xu, Liang Pengfei, Journal of cellular biochemistry. . 2018,第2期

机译：XIST / MIR-29A / LIN28A途径在热损伤后变性的真皮和人体皮肤成纤维细胞（HSF）的作用
4. Effects of estrogens on extracellular matrix synthesis in cultures of human normal and scleroderma skin fibroblasts [C] . Stefano Soldano, Paola Montagna, Renata Brizzolara, International Conference on the Neuroendocrine Immune Basis of the Rheumatic Diseases . 2010

机译：雌激素对人正常和硬皮病皮肤成纤维细胞细胞外基质合成的影响
5. Influence of mechanical cues and the extracellular matrix on patterns of cell migration and rates of proliferation [D] . Alger, Tara. 2013

机译：机械提示和细胞外基质对细胞迁移模式和增殖速率的影响
6. Mechanical force promotes the proliferation and extracellular matrix synthesis of human gingival fibroblasts cultured on 3D PLGA scaffolds via TGF-β expression [O] . Lan Nan, Yi Zheng, Ni Liao, -1

机译：机械力通过TGF-β表达促进在3D PLGA支架上培养的人牙龈成纤维细胞的增殖和细胞外基质合成
7. LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury [O] . Wei Cao, Youping Feng 2019

机译：LNCRNA XIST通过靶向热损伤后的人体皮肤成纤维细胞中的miR-29b-3p / col1a1来促进细胞外基质合成，增殖和迁移
8. Extracellular Matrix Regulations of Membrane Type 1-Matrix Metalloproteinase (MT1-MMP) and Matrix Metalloproteinase-2 (MMP-2) in Human Breast Fibroblasts. [R] . Hernandez-Barrantes, S., Fridman, R. 2002

机译：人乳腺成纤维细胞膜型1基质金属蛋白酶（mT1-mmp）和基质金属蛋白酶-2（mmp-2）的细胞外基质调节。

LncRNA XIST promotes extracellular matrix synthesis proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury

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