Development evaluation and application of 3D QSAR Pharmacophore model in the discovery of potential human renin inhibitors

摘要

BackgroundRenin has become an attractive target in controlling hypertension because of the high specificity towards its only substrate, angiotensinogen. The conversion of angiotensinogen to angiotensin I is the first and rate-limiting step of renin-angiotensin system and thus designing inhibitors to block this step is focused in this study.