Statistical extraction of Drosophila cis-regulatory modules using exhaustive assessment of local word frequency

摘要

BackgroundTranscription regulatory regions in higher eukaryotes are often represented by cis-regulatory modules (CRM) and are responsible for the formation of specific spatial and temporal gene expression patterns. These extended, ~1 KB, regions are found far from coding sequences and cannot be extracted from genome on the basis of their relative position to the coding regions.