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Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway

机译：金属硫蛋白1G通过调节PI3K / Akt信号通路在甲状腺癌中起抑癌作用

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摘要

BackgroundMT1G inactivation mediated by promoter methylation has been reported in thyroid cancer. However, the role of MT1G in thyroid carcinogenesis remains unclear. The aim of this study is to examine the biological functions and related molecular mechanisms of MT1G in thyroid cancer.

机译：背景技术在甲状腺癌中已经报道了由启动子甲基化介导的MT1G失活。但是，MT1G在甲状腺癌变中的作用仍不清楚。这项研究的目的是检查甲状腺癌MT1G的生物学功能和相关的分子机制。

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期刊名称 BMC Cancer
作者
Jiao Fu; Hongjun Lv; Haixia Guan; Xiaoying Ma; Meiju Ji; Nongyue He; Bingyin Shi; Peng Hou;
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作者单位

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年(卷),期 2013(13),-1
年度 2013
页码 462
总页数 13
原文格式 PDF
正文语种
中图分类肿瘤学 ;
关键词
Thyroid cancer Metallothionein 1G (MT1G) DNA methylation PI3K/Akt pathway Rb/E2F pathway;

机译：甲状腺癌;金属硫蛋白1G（MT1G）;DNA甲基化;PI3K / Akt途径;Rb / E2F途径;

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专利

1. Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway [J] . Jiao Fu, Hongjun Lv, Haixia Guan, BMC Cancer . 2013 ,第1期

机译：金属硫蛋白1G通过调节PI3K / Akt信号通路在甲状腺癌中起抑癌作用
2. Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway [J] . Jiao Fu, Hongjun Lv, Haixia Guan, BMC Cancer . 2013 ,第1期

机译：金属硫蛋白1G通过调节PI3K / Akt信号通路在甲状腺癌中起抑癌作用
3. RhoE functions as a tumor suppressor in esophageal squamous cell carcinoma and modulates the PTEN/PI3K/Akt signaling pathway [J] . Hui Zhao, Jianping Yang, Tianli Fan, Tumor Biology . 2012 ,第5期

机译：RhoE在食管鳞状细胞癌中起抑癌作用，并调节PTEN / PI3K / Akt信号通路
4. Inspecting the Role of PI3K/AKT Signaling Pathway in Cancer Development Using an In Silico Modeling and Simulation Approach [C] . Pedro Pablo Gonzalez-Perez, Maura Cardenas-Garcia International work-conference on bioinformatics and biomedical engineering . 2018

机译：使用计算机模拟和仿真方法检查PI3K / AKT信号通路在癌症发展中的作用
5. Sensitivity of MCF-7 breast cancer cells to anticancer drugs is decreased by activation of the PI3K/PDK/Akt signal transduction pathway. [D] . Navolanic, Patrick M. 2004

机译：通过激活PI3K / PDK / Akt信号转导途径，MCF-7乳腺癌细胞对抗癌药物的敏感性降低。
6. Zinc-finger protein 545 is inactivated due to promoter methylation and functions as a tumor suppressor through the Wnt/β-catenin PI3K/AKT and MAPK/ERK signaling pathways in colorectal cancer [O] . Shili Xiang, Tingxiu Xiang, Qian Xiao, -1

机译：锌指蛋白545因启动子甲基化而失活并通过Wnt /β-cateninPI3K / AKT和MAPK / ERK信号通路在大肠癌中起抑癌作用
7. Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway [O] . 2013

机译：金属硫蛋白1G通过调节PI3K / Akt信号通路在甲状腺癌中起抑癌作用

Metallothionein 1G functions as a tumor suppressor in thyroid cancer through modulating the PI3K/Akt signaling pathway

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