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The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish

机译：小分子Mek1 / 2抑制剂U0126破坏了斑马鱼的中胚层向脊索转变

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BackgroundKey molecules involved in notochord differentiation and function have been identified through genetic analysis in zebrafish and mice, but MEK1 and 2 have so far not been implicated in this process due to early lethality (Mek1-/-) and functional redundancy (Mek2-/-) in the knockout animals.

机译：背景已通过遗传分析在斑马鱼和小鼠中鉴定了与脊索动物分化和功能有关的关键分子，但由于早期致死率（Mek1-/-）和功能冗余（Mek2-/- ）在淘汰赛动物中。

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期刊名称 BMC Developmental Biology
作者
Thomas A Hawkins; Florencia Cavodeassi; Ferenc Erdélyi; Gábor Szabó; Zsolt Lele;
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作者单位

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年(卷),期 2008(8),-1
年度 2008
页码 42
总页数 18
原文格式 PDF
正文语种
中图分类进化论、生物系统发育;
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专利

1. The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish [J] . Thomas A Hawkins, Florencia Cavodeassi, Ferenc Erdélyi, BMC Developmental Biology . 2008,第1期

机译：小分子Mek1 / 2抑制剂U0126破坏了斑马鱼的中胚层向脊索转变
2. mTOR inhibitor temsirolimus and MEK1/2 inhibitor U0126 promote chromosomal instability and cell type-dependent phenotype changes of glioblastoma cells [J] . AA Stepanenko, S.V. Andreieva, K.V. Korets, Gene: An International Journal Focusing on Gene Cloning and Gene Structure and Function . 2016,第1期

机译：mTOR抑制剂temsirolimus和MEK1 / 2抑制剂U0126促进胶质母细胞瘤细胞的染色体不稳定和细胞类型依赖性表型变化
3. MEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia, and improves outcome after subarachnoid hemorrhage in rats [J] . Povlsen Gro K., Edvinsson Lars Journal of Cerebral Blood Flow and Metabolism: Official Journal of the International Society of Cerebral Blood Flow and Metabolism . 2015,第2期

机译：MEK1 / 2抑制剂U0126而不是内皮素受体拮抗剂克拉佐森减少大鼠脑蛛网膜下腔出血后脑血管收缩受体的上调和延迟脑缺血，并改善结局
4. Balancing the MRM transition of small molecule substrate/product conversions for enhanced label-free enzyme inhibitor screening [C] . Rakesh Rathore, Jay Corr, Kenneth D. Greis American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2009

机译：平衡小分子底物/产物转换的MRM转变，用于增强的无标记酶抑制剂筛选
5. Mechanisms of copper-dependent notochord formation in zebrafish . [D] . Gansner, John Michael. 2010

机译：斑马鱼中铜依赖性脊索形成的机理。
6. MEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia and improves outcome after subarachnoid hemorrhage in rats [O] . Gro K Povlsen, Lars Edvinsson 2015

机译：MEK1 / 2抑制剂U0126而不是内皮素受体拮抗剂克拉佐森减少大鼠脑血管收缩性受体的上调和延迟脑缺血并改善蛛网膜下腔出血后的结局
7. The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish [O] . 2008

机译：小分子Mek1 / 2抑制剂U0126破坏了斑马鱼的中胚层向脊索转变

The small molecule Mek1/2 inhibitor U0126 disrupts the chordamesoderm to notochord transition in zebrafish

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