isolated nucleic acid molecule encoding a mutant mek1 protein having mek1 activity, expression vector, host cell, method of producing a mutant mek1 protein, isolated mutant mek1 protein, method of identifying a patient who has cancer, method of optimizing treating a cancer patient, and using a raf inhibitor and a mek inhibitor.

摘要

isolated nucleic acid molecule encoding a mutant mek1 protein having mek1 activity, expression vector, host cell, method of producing a mutant mek1 protein, isolated mutant mek1 protein, method of identifying a patient who has cancer, method of optimizing treatment of a cancer patient, and use of a raf inhibitor and a mek inhibitor. nucleic acids and proteins having a mutant mek sequence, and methods for identifying patients having resistance to treatment with anticancer agents, specifically raf or mek inhibitors, are provided. Treatment methods and for optimizing treatment and for optimizing treatment for patients having a mutation in a mek1 sequence are also provided.