A novel predictive factor for the onset time of docetaxel-induced onychopathy: a multicenter retrospective study

摘要

BackgroundTaxanes are known to cause onychopathy. Previous studies have reported the relationship between onychopathy and paclitaxel dosing intervals and cumulative doses. However, there are no studies of the predictive factors for docetaxel-induced nail changes. The present study used the drug accumulation rate (mg/m²/day) as a novel indicator and evaluated its usefulness for the prediction of onychopathy.