Associations of vitamin D deficiency and vitamin D receptor (Cdx-2 Fok I Bsm I and Taq I) polymorphisms with the risk of primary open-angle glaucoma

摘要

BackgroundVitamin D deficiency and vitamin D receptor gene polymorphisms are known to be significantly associated with high myopia. Whether this genetic variant may impact primary open-angle glaucoma is largely unknown. This study investigated whether vitamin D receptor gene polymorphisms are altered in primary open-angle glaucoma subjects carrying the risk allele, and whether vitamin D deficiency is an important factor in the development of glaucoma.