Tissue inhibitor of metalloproteinase 4 in aqueous humor of patients with primary open angle glaucoma pseudoexfoliation syndrome and pseudoexfoliative glaucoma and its role in proteolysis imbalance

摘要

BackgroundTo quantify the levels of tissue inhibitor of metalloproteinase 4 (TIMP4) and its ratios with free metalloproteinases (MMP) in the aqueous humor of patients with primary open angle glaucoma (POAG), pseudoexfoliation syndrome (PXS) and pseudoexfoliative glaucoma (PXG) and to evaluate a possible imbalance between MMPs and TIMPs in these samples.