The role played by oxidative stress in evoking the exercise pressor reflex in health and simulated peripheral artery disease

摘要

Key points class="unordered" style="list-style-type:disc" id="tjp12363-list-0001">Ligating the femoral artery of a rat for 72 h, a model for peripheral artery disease, causes an exaggerated exercise pressor reflex in response to muscle contraction.Likewise, the hindlimb muscles of rats with ligated femoral arteries show increased levels of reactive oxygen species.Infusion of tiron, a superoxide scavenger, attenuated the exaggerated pressor reflex and reduced reactive oxygen species production in rats with ligated femoral arteries.Conversely, we found no effect of tiron infusion on the pressor reflex in rats with patent femoral arteries.These results suggest a role of reactive oxygen species with respect to causing the exaggerated pressor response to contraction seen in rats with ligated arteries and peripheral artery disease.