Efficacy of 1 5 and 20 mg oral sildenafil in the treatment of adults with pulmonary arterial hypertension: a randomized double-blind study with open-label extension

摘要

BackgroundIn a previous study, 6-minute walk distance (6MWD) improvement with sildenafil was not dose dependent at the 3 doses tested (20, 40, and 80 mg 3 times daily [TID]). This study assessed whether lower doses were less effective than the approved 20-mg TID dosage.