Genome-wide analysis of the transcription factor binding preference of human bi-directional promoters and functional annotation of related gene pairs

摘要

BackgroundBi-directional gene pairs have received considerable attention for their prevalence in vertebrate genomes. However, their biological relevance and exact regulatory mechanism remain less understood. To study the inner properties of this gene organization and the difference between bi- and uni-directional genes, we conducted a genome-wide investigation in terms of their sequence composition, functional association and regulatory motif discovery.