双向调节蛋白、转录因子 E2 启动子结合因子 1 、白细胞介素6 的表达与结直肠癌发生发展的相关性

摘要

Objective To observe the expression of Two way regulatory protein (amphiregulin,AREG),tran－scription factor E2 promoter binding factor 1 (E2F－1),interleukin －6 (IL－6).in patients with colorectal cancer and to analyze its clinical significance.Methods The patients with colorectal cancer who were treated in our hospital from Au－gust 2015 to July in 2017 were selected as the subjects.Meanwhile,the patients with colon polyps who were treated in our hospital during the same period were selected as the control group.The expressions of AREG,transcription factor E2F－1 and IL－6 in two groups were observed.The expressions of AREG,transcription factor E2F－1 and IL－6 in different clinicopathological characteristics were compared ,and the factors influencing AREG ,transcription factor E2F－1 and IL－6 expression were analyzed.Results The AREG and IL－6 levels of colorectal cancer patients and the positive expression rate of transcription factor E2F－1 were higher than those in the colorectal polyp group.The AREG and IL－6 levels of colorectal cancer patients with lymph node metastasis and histological type were mucinous adenocarcinoma and stage TNM stage Ⅲ+Ⅳ.The positive rate of transcription factor E 2F－1 was high.The single factor analysis showed lymph node metastasis,histological type and TNM stage were the dependent variable ,the AREG and IL－6 levels in patients with colorectal cancer, the positive expression of transcription factor E 2F－1 as independent variables.Regression analysis showed that the histological type and TNM stage were the factors affecting the expression .Conclusion The AREG and IL－6 levels of colorectal cancer patients ,the positive expression rate of transcription factor E 2F－1 are higher,and the his－tological and TNM stages are the factors that affect the expression level.%目的 观察结直肠癌患者的双向调节蛋白(AREG)、转录因子E2启动子结合因子1(E2F－1)、白细胞介素6(IL－6)的表达情况,并分析其临床意义.方法 选取在住院接受治疗的结直肠癌患者为研究对象,同时选取同期住院接受治疗的结肠息肉患者作为对照.观察两组患者AREG、转录因子E2F－1、IL－6的表达,比较不同临床病理特征结直肠癌患者的AREG、转录因子E2F－1、IL－6的表达,分析影响AREG、转录因子E2F－1、IL－6表达的因素.结果 结直肠癌患者的AREG、IL－6水平,转录因子E2F－1阳性表达率高于结直肠息肉组;有淋巴结转移、组织学分型为黏液腺癌、TNM分期为Ⅲ期+Ⅳ期的结直肠癌患者的AREG、IL－6水平,转录因子E2F－1阳性表达率较高;回归分析结果显示组织学分型和TNM分期是影响表达的因素.结论 结直肠癌患者的AREG、IL－6水平,转录因子E2F－1阳性表达率较高,相关因子的表达与结直肠癌的组织学分型和TNM分期具有一定的相关性.