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Prognostic significance of circulating microRNA-214 and -126 in dogs with appendicular osteosarcoma receiving amputation and chemotherapy

机译：截肢和化学疗法治疗犬阑尾骨肉瘤中循环microRNA-214和-126的预后意义

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摘要

BackgroundDogs with appendicular osteosarcoma (OSA) receiving standard amputation and adjuvant chemotherapy demonstrate variable outcome with treatment; however, additional biomarkers would be helpful for predicting their outcome. In the present study, we assessed the potential of circulating microRNA-214 (miR-214) and − 126 (miR-126) to predict time to metastasis and death in dogs with OSA treated with amputation and chemotherapy.

机译：接受标准截肢术和辅助化疗的患有阑尾骨肉瘤（OSA）的狗表现出不同的治疗效果；然而，额外的生物标志物将有助于预测其结果。在本研究中，我们评估了循环microRNA-214（miR-214）和-126（miR-126）预测通过截肢和化学疗法治疗的OSA狗的转移和死亡时间的潜力。

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期刊名称 BMC Veterinary Research
作者
Kazuki Heishima; Travis Meuten; Kyoko Yoshida; Takashi Mori; Douglas H. Thamm;
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作者单位

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年(卷),期 2019(15),-1
年度 2019
页码 39
总页数 13
原文格式 PDF
正文语种
中图分类动物医学（兽医学）;
关键词
Bone Cancer Canine Prognosis Biomarker Comparative oncology;

机译：骨;癌症;犬;预后;生物标志物;比较肿瘤学;

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专利

1. Prognostic significance of circulating microRNA-214 and -126 in dogs with appendicular osteosarcoma receiving amputation and chemotherapy [J] . Kazuki Heishima, Travis Meuten, Kyoko Yoshida, BMC Veterinary Research . 2019,第1期

机译：具有截肢截肢和化疗患者患者循环microRNA-214和-126的预后意义
2. Evaluation of metronomic cyclophosphamide chemotherapy as maintenance treatment for dogs with appendicular osteosarcoma following limb amputation and carboplatin chemotherapy [J] . Matsuyama Arata, Schott Courtney R., Wood Geoffrey A., Journal of the American Veterinary Medical Association . 2018,第11期

机译：肢体截肢术后术后术后术后血管病毒环磷酰胺化学疗法的评价
3. Comparison of Carboplatin and Doxorubicin-Based Chemotherapy Protocols in 470 Dogs after Amputation for Treatment of Appendicular Osteosarcoma [J] . Selmic L. E., Burton J. H., Thamm D. H., Journal of Veterinary Internal Medicine . 2014,第2期

机译：470例截肢治疗阑尾骨肉瘤犬中卡铂和基于阿霉素的化疗方案的比较
4. TREATMENT OF CANINE APPENDICULAR OSTEOSARCOMA WITH AMPUTATION, CARBOPLATIN, AND TOCERANIB PHOSPHATE [C] . Tracy Gieqer, Dawn Clarke, Julie Nettifee-Osborne, Conference of the American^College^of^Veterinary^Internal^Medicine . 2016

机译：用截肢，卡铂和Toceranib磷酸盐治疗犬阑尾骨肉瘤
5. Comparison of Carboplatin and Doxorubicin‐Based Chemotherapy Protocols in 470 Dogs after Amputation for Treatment of Appendicular Osteosarcoma [O] . L.E. Selmic, J.H. Burton, D.H. Thamm, 2014

机译：470例截肢治疗阑尾骨肉瘤的犬中卡铂和基于阿霉素的化学疗法方案的比较
6. Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study. [O] . Cheryl A London, Heather L Gardner, Tamra Mathie, 2015

机译：Toceranib /吡罗昔康/环磷酰胺维持治疗对截肢和卡铂化疗后阑尾骨肉瘤患者预后的影响：多机构研究。

Prognostic significance of circulating microRNA-214 and -126 in dogs with appendicular osteosarcoma receiving amputation and chemotherapy

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