Age-dependent remodelling of inhibitory synapses onto hippocampal CA1 oriens-lacunosum moleculare interneurons

摘要

Non-technical summaryThe main function of the inhibitory synapse is to provide the membrane hyperpolarization and, thereby, to control the level of activity of its target cell. Extensively studied in pyramidal neurons, the properties of inhibitory synapses that target inhibitory interneurons remain largely unknown. We studied the properties of inhibitory synapses formed onto interneurons involved in the hippocampal feedback inhibitory circuit. Our data revealed a significant, age-dependent strengthening of inhibition of interneurons due to the synaptic incorporation of the α5 subunit of the GABAA receptor. This novel mechanism of age-dependent refinement of local circuit inhibition may have a direct impact on the hippocampal network activity and performance during development.