Correlation between circulating mutant DNA and metabolic tumour burden in advanced non-small cell lung cancer patients

摘要

Background: Mutated circulating cell-free DNA (cfDNA) has been suggested as a surrogate marker of tumour burden and aggressiveness of disease. We examined the association between the level of plasma mutant cfDNA and metabolic tumour burden (MTB) measured by ¹⁸F-fluoro-D-glucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT). Furthermore, the presence of mutant cfDNA was correlated with patient survival.