The relative efficacy of various types of treatment in preventing metastatic uveal melanoma is unclear. We have performed a phase I-II non-randomised trial to determine if patients with large (greater than 15 mm in diameter or greater than 5 mm in thickness) uveal melanomas would benefit from pre-enucleation irradiation. Twenty-eight patients were treated between 1978 and 1983 by means of 5 X 5 cm anterior wedge pair ports on a 4 me V linear accelerator. Each patient received five 4 gray (400 rad) fractions over a five-day period for a total of 20 Gy. Enucleation was performed by a single surgeon within five days after treatment. The mean follow-up of the patients was 24 months (range 7-54 months). All melanomas were histologically confirmed. Four patients (14%) have developed metastatic tumour with a mean interval between diagnosis and death of 25 months. No significant perioperative or long-term morbidity was observed.
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机译：预防转移性葡萄膜黑色素瘤的各种治疗方法的相对疗效尚不清楚。我们已经进行了I-II期非随机试验，以确定葡萄膜黑色素瘤（直径大于15毫米或厚度大于5毫米）的患者是否将从摘除前的照射中受益。 1978年至1983年，通过4 me V线性加速器上的5 X 5 cm前楔形对端口治疗了28位患者。每位患者在五天内接受了5个4 gray（400 rad）分数，总计20 Gy。在治疗后的五天内由一名外科医生进行摘核。患者的平均随访时间为24个月（范围7-54个月）。所有黑色素瘤均在组织学上得到证实。四名患者（14％）已发展成转移性肿瘤，诊断与死亡之间的平均间隔为25个月。没有观察到明显的围手术期或长期发病率。
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