Cytochrome P450‐mediated interaction between perazine and risperidone: implications for antipsychotic polypharmacy

摘要

BackgroundAlthough clinically widespread, scientific evidence for antipsychotic polypharmacy is still limited. Combining different drugs increases the potential for drug–drug interactions, enhancing the risk of adverse drug reactions. We aimed to unravel the potential pharmacokinetic interactions between risperidone (RIS) and perazine.