CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease

机译：CYP3A5基因多态性影响终末期肾脏疾病患者活肾移植后CYP3A活性的增加

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AimsIt has been reported that cytochrome P450 (CYP)3A activity increases significantly in patients with end stage renal disease (ESRD) after kidney transplantation, with wide interindividual variability in the degree of increase. The aim of this study was to evaluate the influence of CYP3A5 polymorphism on the increase in CYP3A activity after living kidney transplantation, by measuring the plasma concentration of 4β‐hydroxycholesterol.

机译：目的据报道，肾移植后患有终末期肾病（ESRD）的患者细胞色素P450（CYP）3A活性显着增加，个体间差异很大。这项研究的目的是通过测量4β-羟基胆固醇的血浆浓度来评估CYP3A5多态性对活肾移植后CYP3A活性增加的影响。

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期刊名称 British Journal of Clinical Pharmacology
作者
Yosuke Suzuki; Takashi Fujioka; Fuminori Sato; Kunihiro Matsumoto; Nanako Muraya; Ryota Tanaka; Yuhki Sato; Keiko Ohno; Hiromitsu Mimata; Satoshi Kishino; Hiroki Itoh;
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作者单位

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年(卷),期 2015(80),6
年度 2015
页码 1421–1428
总页数 8
原文格式 PDF
正文语种
中图分类药学;
关键词
4β‐hydroxycholesterol CYP3A activity CYP3A5 polymorphism kidney transplantation;

机译：4β-羟基胆固醇;CYP3A活性;CYP3A5多态性;肾移植;

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专利

1. CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease [J] . Suzuki Yosuke, Fujioka Takashi, Sato Fuminori, British Journal of Clinical Pharmacology . 2015,第6期

机译：CYP3A5基因多态性影响终末期肾脏疾病患者活肾移植后CYP3A活性的增加
2. CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease [J] . Suzuki Yosuke, Fujioka Takashi, Sato Fuminori, British journal of clinical pharmacology . 2015,第6期

机译：CYP3A5基因多态性影响终末期肾脏疾病患者活肾移植后CYP3A活性的增加
3. Effect of genetic polymorphisms of CYP3A5 and MDR1 on cyclosporine concentration during the early stage after renal transplantation in Chinese patients co-treated with diltiazem. [J] . Wang Y, Wang C, Li J, European journal of clinical pharmacology . 2009,第3期

机译：CYP3A5和MDR1基因多态性对地尔硫卓联合治疗的中国患者肾移植早期环孢素浓度的影响。
4. Influence of CYP3A5 polymorphism on tacrolimus blood concentrations in renal transplant patients [C] . NIE Xin-min, GUI Rong, ZHAO Hong-shan, Postdoctoral Symposium for Celebration of 20th Anniversary of the Foundation of Chinese Postdoctoral System; 2005; . 2005

机译：CYP3A5基因多态性对肾移植患者他克莫司血药浓度的影响
5. A Retrospective Analysis of Renal Transplant Outcomes: induction Immunosuppression with Anti-thymocyte Globulin vs. Alemtuzumab in patients undergoing Deceased and Living Donor Kidney Transplantation. [D] . DiMartino, Debra A. 2012

机译：肾移植结果的回顾性分析：死者和活体供者肾脏移植患者中抗胸腺细胞球蛋白与Alemtuzumab的诱导免疫抑制作用。
6. Capability of Utilizing CYP3A5 Polymorphisms to Predict Therapeutic Dosage of Tacrolimus at Early Stage Post-Renal Transplantation [O] . Takenori Niioka, Hideaki Kagaya, Mitsuru Saito, 2015

机译：利用CYP3A5基因多态性预测他克莫司在肾移植后早期治疗剂量的能力
7. Influence of Cytochrome P450 (CYP) 3A4*1G Polymorphism on the Pharmacokinetics of Tacrolimus, Probability of Acute Cellular Rejection, and mRNA Expression Level of CYP3A5 Rather than CYP3A4 in Living-Donor Liver Transplant Patients [O] . Miwa Uesugi, Mio Hosokawa, Haruka Shinke, 2013

机译：细胞色素P450（CYP） 3a4 * 1g对诱导肝脏移植患者的CYP3A5的急性细胞排斥，急性细胞排斥，急性细胞排斥的概率和MRNA表达水平的影响

CYP3A5 polymorphism affects the increase in CYP3A activity after living kidney transplantation in patients with end stage renal disease

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